To me, a key factor for winning in Fantasy Football is drafting "safe" players. In order to draft "safe" players, the first thing you need to do is asses the risk factor of players you want on your team.
The risk factors of players can be assessed anywhere from their health status throughout the season to their statistical consistency when playing. Also, the risk in players is determined by whether they were put on a new team, if the system fits well with the player, or whether the player will be able to work well with the players on their team.
Here are the players I think are the least prone to injury as well as who are the least riskiest players to draft this season in fantasy football based( by position):
QB:
Patrick Mahomes
Deshaun Watson
Matt Ryan
Drew Brees
Russel Wilson
Baker Mayfield
Tom Brady
Jared Goff
RB:
Saquon Barkely
Christian McCaffrey
Ezekiel Elliot
Alvin Kamara
Nick Chubb
Joe Mixon
Derrick Henry
Damien Williams
Aaron Jones
Marlon Mack
Mark Ingram
Chris Carson
Tevin Coleman
Jordan Howard
Tarik Cohen
Frank Gore
WR:
DeAndre Hopkins
Julio Jones
Davante Adams
Michael Thomas
Mike Evans
Keenan Allen
Tyreek Hill
Adam Thielen
Stefon Diggs
Brandin Cooks
Julian Edelman
Robert Woods
Kenny Golladay
Tyler Lockett
Chris Godwin
Tyler Boyd
Cooper Kupp
Larry Fitzgerald
Golden Tate
Emmanuel Sanders
TE:
Zach Ertz
Travis Kelce
Eric Ebron
Evan Engram
K:
Steven Gostkowski
Will Lutz
Harrison Butker
Justin Tucker
Matt Prater
Chris Boswell
Chandler Cantanzaro
Robby Gould